B plexins activate Rho through PDZ-RhoGEF.

  title={B plexins activate Rho through PDZ-RhoGEF.},
  author={Mariette H E Driessens and Cristina Olivo and Koh-Ichi Nagata and Masaki Inagaki and John G. Collard},
  journal={FEBS letters},
  volume={529 2-3},
Plexins are receptors for the repulsive axon guidance molecules semaphorins. Previously, we have shown that plexin-B1 binds activated Rac, but that clustering of plexin-B1 causes Rho activation, resulting in stress fiber formation. Using the yeast two-hybrid system, we found that the C-terminus of B plexins interacted directly with Rho-specific exchange factors, via their PDZ domain. Mutation of the carboxy-terminal amino acids of plexin-B1 or coexpression of a dominant negative PDZ-RhoGEF… CONTINUE READING


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