B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.

@article{Baker2014BmybIA,
  title={B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.},
  author={Stacey J. Baker and Avi Ma'ayan and Yen K. Lieu and Premila John and M. Venkata Ramana Reddy and Edward L Y Chen and Qiaonan Duan and H. -W. Snoeck and E. P. Reddy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 8},
  pages={3122-7}
}
The B-myb (MYBL2) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation, DNA replication, and maintenance of genomic integrity. However, its function during adult development and hematopoiesis is unknown. We show here that conditional inactivation of B-myb in vivo results in depletion of the hematopoietic stem cell (HSC) pool, leading to profound reductions in mature lymphoid, erythroid, and myeloid cells. This defect is autonomous to the bone… CONTINUE READING

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B - myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development .
TRANSCRIPTION FACTORIs biochemical function of gene productOncogene Proteins v-myb
The B - myb ( MYBL2 ) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation , DNA replication , and maintenance of genomic integrity .
B - myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development .
Cell Cycle ControlProcess involves geneMYBL2 gene
The B - myb ( MYBL2 ) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation , DNA replication , and maintenance of genomic integrity .
The B - myb ( MYBL2 ) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation , DNA replication , and maintenance of genomic integrity .
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