B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

@article{Shiu2015BlymphocytesSA,
  title={B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.},
  author={Kin Yee Shiu and Laura McLaughlin and Irene Rebollo-Mesa and Jingyue Zhao and Vikki Semik and H Terence Cook and Candice A. Roufosse and Paul Andrew Brookes and Robert W Bowers and Jack Galliford and David J. Taube and R. Lechler and Maria P Hernandez-Fuentes and Anthony Dorling},
  journal={Kidney international},
  year={2015},
  volume={88 3},
  pages={
          560-8
        }
}
We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14 patients with AMR and 5 with no pathology on protocol; 38 with AMR and 8 with nonimmunologic damage on 'for cause'. Using enzyme-linked immunosorbent spot assays, we found interferon-γ production by indirect… CONTINUE READING
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