B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes

@article{Ronchese1993BLI,
  title={B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes},
  author={Franca Ronchese and B Hausmann},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={679 - 690}
}
The ability of B cells or macrophages and dendritic cells (DC) to elicit class II-restricted T cell responses in vivo was compared using a mouse chimera model. Severe combined immunodeficient (SCID) mice (H-2d), reconstituted either with T or T+B lymphocytes from (H-2d x H-2b) donors, were immunized subcutaneously with protein antigen (Ag) to induce a class II-restricted T cell response. The frequency and major histocompatibility complex restriction of the resulting Ag-specific T cells were… CONTINUE READING

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