B lymphocytes from patients with chronic lymphoproliferative disorders are equipped with different costimulatory molecules.

@article{Trentin1997BLF,
  title={B lymphocytes from patients with chronic lymphoproliferative disorders are equipped with different costimulatory molecules.},
  author={Livio Trentin and Renato Zambello and Rosaria Sancetta and Monica Facco and Andrea Cerutti and Alessandra Perin and Marta Siviero and Umberto Basso and Michela Bortolin and Fausto Adami and Carlo Agostini and Gianpietro Semenzato},
  journal={Cancer research},
  year={1997},
  volume={57 21},
  pages={4940-7}
}
Several costimulatory molecules play a key role in the differentiation of B lymphocytes and in T-B-cell interactions. In this study, we addressed the question of whether different receptors and counter-receptors may be expressed on malignant B lymphocytes from chronic B-cell malignancies. Using flow cytometry and reverse transcription PCR analyses, the expression of molecules belonging to the tumor necrosis factor receptor (TNFR) and tumor necrosis factor ligand (TNFL) families, as well as the… CONTINUE READING