B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis

@inproceedings{Franois2013BLA,
  title={B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis},
  author={Antoine François and Emmanuel Chatelus and Dominique Wachsmann and Jean Sibilia and Seiamak Bahram and Ghada Alsaleh and Jacques-Eric Gottenberg},
  booktitle={Arthritis Research & Therapy},
  year={2013}
}
IntroductionB lymphocytes might play a pathogenic role in dermal fibrosis in systemic sclerosis (SSc). B-cell activating factor (BAFF), a key cytokine for B-cell activation, is increased in the serum and the skin of patients with SSc. However, the ability of B cells directly to stimulate dermal fibroblasts and the role of BAFF are not fully understood. We therefore investigated the involvement of B cells and BAFF in the expression of collagen and profibrotic markers by dermal fibroblasts… CONTINUE READING

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