B-lymphocyte tolerance and effector function in immunity and autoimmunity.

  title={B-lymphocyte tolerance and effector function in immunity and autoimmunity.},
  author={Wasif Noor Khan and Jacqueline A. Wright and Eden Kleiman and Justin C Boucher and Iris Castro and Emily S. Clark},
  journal={Immunologic research},
  volume={57 1-3},
B-lymphocytes are integral to host defense against microbial pathogens and are associated with many autoimmune diseases. The B-cell receptor implements B-cell self-tolerance based on the antigen specificity, and B-cell-activating factor receptor (BAFF-R) imposes homeostatic control. While shaping the repertoire, the immune tolerance process also culls mature B cells into distinct populations. The activation response of B cells is tailored to the type of pathogen attack and is facilitated by T… CONTINUE READING
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