B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection

@article{Voswinkel2001BLI,
  title={B lymphocyte involvement in ankylosing spondylitis: the heavy chain 
variable segment gene repertoire of B lymphocytes from germinal center-like 
foci in the synovial membrane indicates antigen selection},
  author={Jan Voswinkel and Kerstin Weisgerber and Michael Pfreundschuh and Angela Gause},
  journal={Arthritis Research},
  year={2001},
  volume={3},
  pages={189 - 195}
}
The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to rheumatoid arthritis (RA). We characterized the rearranged heavy chain variable segment (VH) genes in the SM for gene usage and the mutational pattern to elucidate the B lymphocyte involvement in AS. Cryosections from an AS-derived SM were stained for B and T lymphocytes. B cells were isolated from different areas of a focus. The… CONTINUE READING
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