B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.

@article{Salehi2012BLM,
  title={B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.},
  author={Soofia Salehi and Rashmi Bankoti and Luciana Benevides and Jessica Willen and Michael Couse and Jo{\~a}o S. Silva and Deepti Dhall and Eric Meffre and Stephan Raoul Targan and Gisl{\^a}ine Aparecida Martins},
  journal={Journal of immunology},
  year={2012},
  volume={189 12},
  pages={5682-93}
}
The transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) plays important roles in embryonic development and immunity. Blimp-1 is required for the differentiation of plasma cells, and mice with T cell-specific deletion of Blimp-1 (Blimp-1CKO mice) develop a fatal inflammatory response in the colon. Previous work demonstrated that lack of Blimp-1 in CD4(+) and CD8(+) T cells leads to intrinsic functional defects, but little is known about the functional role of Blimp-1 in… CONTINUE READING
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