B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.

@article{Parsons2010BlymphocyteHA,
  title={B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.},
  author={Ronald F. Parsons and Kumar Vivek and Robert R Redfield and T Migone and Michael P. Cancro and Ali Naji and Hooman Noorchashm},
  journal={Transplantation reviews},
  year={2010},
  volume={24 4},
  pages={207-21}
}
Current strategies for immunotherapy after transplantation are primarily T-lymphocyte directed and effectively abrogate acute rejection. However, the reality of chronic allograft rejection attests to the fact that transplantation tolerance remains an elusive goal. Donor-specific antibodies are considered the primary cause of chronic rejection. When naive, alloreactive B-cells encounter alloantigen and are activated, a resilient "sensitized" state, characterized by the presence of high-affinity… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

B-cell regulation and its application to transplantation.

Transplant international : official journal of the European Society for Organ Transplantation • 2014
View 2 Excerpts

Essential role for B cells in transplantation tolerance.

Current opinion in immunology • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…