B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.

  title={B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.},
  author={Ronald F. Parsons and Kumar Vivek and Robert R Redfield and T Migone and Michael P. Cancro and Ali Naji and Hooman Noorchashm},
  journal={Transplantation reviews},
  volume={24 4},
Current strategies for immunotherapy after transplantation are primarily T-lymphocyte directed and effectively abrogate acute rejection. However, the reality of chronic allograft rejection attests to the fact that transplantation tolerance remains an elusive goal. Donor-specific antibodies are considered the primary cause of chronic rejection. When naive, alloreactive B-cells encounter alloantigen and are activated, a resilient "sensitized" state, characterized by the presence of high-affinity… CONTINUE READING


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