B-lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting.

@article{Matsushita2009BlymphocyteDF,
  title={B-lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting.},
  author={Takashi Matsushita and Thomas F. Tedder},
  journal={Expert review of neurotherapeutics},
  year={2009},
  volume={9 3},
  pages={309-12}
}
Conventional wisdom is that B lymphocytes are a major driving force behind autoantibody-dependent autoimmune diseases, such as systemic lupus erythematosus, and the autoimmune blistering diseases, such as pemphigus vulgaris. Other autoimmune diseases have been classically viewed as predominantly T-cell-dependent, such as multiple sclerosis (MS), rheumatoid arthritis, systemic sclerosis and Type 1 diabetes. This conclusion derives from the finding that adoptive transfer of T cells from diseased… CONTINUE READING

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