B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

@article{Murphy1997BLA,
  title={B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?},
  author={Tanya K. Murphy and Wayne K. Goodman and Mitzie Fudge and Robert Charles Williams and Elia M. Ayoub and Mansi Dalal and Maureen Helen Lewis and John B. Zabriskie},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 3},
  pages={
          402-7
        }
}
OBJECTIVE It has been hypothesized that Sydenham's chorea, a major manifestation of rheumatic fever, may provide a medical model for obsessive-compulsive disorder and associated conditions, such as Tourette's syndrome. Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in nearly all patients with rheumatic fever and is thought to be a trait marker for susceptibility to this complication of group A streptococcal infection. The authors investigated whether D8/17… CONTINUE READING
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