B-lymphocyte activating factor levels are increased in patients with Wegener’s granulomatosis and inversely correlated with ANCA titer

@article{Bader2010BlymphocyteAF,
  title={B-lymphocyte activating factor levels are increased in patients with Wegener’s granulomatosis and inversely correlated with ANCA titer},
  author={Lucius Bader and Wenche Koldingsnes and Johannes C Nossent},
  journal={Clinical Rheumatology},
  year={2010},
  volume={29},
  pages={1031-1035}
}
Circulating autoantibodies against neutrophils (ANCA) are a distinctive finding in patients with Wegener’s granulomatosis (WG). B-lymphocyte activating factor (BAFF) promotes autoantibody production by increasing B cell survival and proliferation. We investigated serum BAFF levels (s-BAFF) in a WG patient cohort in relation to ANCA titers and disease activity. Baseline data were obtained in twenty-two WG patients (55% female, age 44 years, disease duration 1 year). S-BAFF was determined by… CONTINUE READING
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