B-hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.

Abstract

BACKGROUND & AIMS Sterile inflammation resulting in alcohol hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors responsible for the development of AH are not known but mitochondrial damage with loss of mitochondrial function are common features. Hcar2 is a G-protein coupled receptor which is activated by… (More)
DOI: 10.1016/j.jhep.2018.04.004

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