B cells within germinal centers migrate preferentially from dark to light zone.

@article{Beltman2011BCW,
  title={B cells within germinal centers migrate preferentially from dark to light zone.},
  author={Joost B. Beltman and Christopher D C Allen and Jason G Cyster and Rob J. de Boer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 21},
  pages={
          8755-60
        }
}
One of the main questions in the field of imaging immune cell migration in living tissues is whether cells fulfill their functionality via random or nonrandom migration processes. For some applications, this issue has remained controversial even after publication of various imaging studies. A prime example is B-cell migration in germinal centers (GCs) where somatic hypermutation and clonal selection of B cells are thought to occur within morphologically distinct regions termed dark zone (DZ… CONTINUE READING

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