B cells under influence: transformation of B cells by Epstein–Barr virus

  title={B cells under influence: transformation of B cells by Epstein–Barr virus},
  author={Ralf K{\"u}ppers},
  journal={Nature Reviews Immunology},
Epstein–Barr virus (EBV) is an extremely successful virus, infecting more than 90% of the human population worldwide. After primary infection, the virus persists for the life of the host, usually as a harmless passenger residing in B cells. However, EBV can transform B cells, which can result in the development of malignant lymphomas. Intriguingly, the three main types of EBV-associated B-cell lymphoma — that is, Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas — seem to derive… CONTINUE READING
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