B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.

@article{Affara2014BCR,
  title={B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.},
  author={Nesrine I. Affara and Brian Ruffell and Terry R Medler and Andrew J. Gunderson and Magnus C Johansson and Sophia Bornstein and Emily Bergsland and Martin S Steinhoff and Yijin Li and Qian Gong and Yan Ma and Jane Wiesen and Melissa H Wong and Molly Kulesz-Martin and Bryan A. Irving and Lisa M. Coussens},
  journal={Cancer cell},
  year={2014},
  volume={25 6},
  pages={809-821}
}
B cells foster squamous cell carcinoma (SCC) development through deposition of immunoglobulin-containing immune complexes in premalignant tissue and Fcγ receptor-dependent activation of myeloid cells. Because human SCCs of the vulva and head and neck exhibited hallmarks of B cell infiltration, we examined B cell-deficient mice and found reduced support for SCC growth. Although ineffective as a single agent, treatment of mice bearing preexisting SCCs with B cell-depleting αCD20 monoclonal… CONTINUE READING