B cells limit repair after ischemic acute kidney injury.

  title={B cells limit repair after ischemic acute kidney injury.},
  author={Hye Ryoun Jang and Maria Teresa Gandolfo and Gang Jee Ko and Shailesh Ramchandra Satpute and Lorraine C. Racusen and Hamid Rabb},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 4},
There is no established modality to repair kidney damage resulting from ischemia-reperfusion injury (IRI). Early responses to IRI involve lymphocytes, but the role of B cells in tissue repair after IRI is unknown. Here, we examined B cell trafficking into postischemic mouse kidneys and compared the repair response between control (wild-type) and muMT (B cell-deficient) mice with and without adoptive transfer of B cells. B cells infiltrated postischemic kidneys and subsequently activated and… CONTINUE READING