B cells in autoimmunity

  title={B cells in autoimmunity},
  author={Thomas Doerner and Annett Marita Jacobi and Peter E Lipsky},
  booktitle={Arthritis research & therapy},
B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma cells in immune regulation under normal and autoimmune conditions with particular emphasis on systemic lupus… CONTINUE READING
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