B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses

@article{Ireland2016BCF,
  title={B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses},
  author={Sara J Ireland and Alyssa A. Guzman and Elliot M. Frohman and Nancy Monson},
  journal={Journal of Neuroimmunology},
  year={2016},
  volume={291},
  pages={46-53}
}
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22 Citations
Background Citations
8
Results Citations
2

22 Citations

Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
TLDR
The curation of this literature has identified that central nervous system (CNS) infiltrating TFH cells act with TH17 cell to contribute to an inflammatory B cell response in neuroinflammation, demonstrating thatTFH cells and their products are promising targets for therapies in MS.
Increased ex vivo antigen presentation profile of B cells in multiple sclerosis
TLDR
These data suggest that the activation profile of B cells is increased in MS, however, the perception of the danger signal by B lymphocytes and monocytes does not seem to be different in MS patients as compared to control subjects.
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation
TLDR
This study investigated the Tfh cell distribution during disease progression in disease relevant organs in three different EAE models and identified significantly higher levels of T fh cells in the dura mater than in the CNS both in C57BL/6 and in SJL/J mice.
Targeting Antigen-Presenting Cells in Multiple Sclerosis Treatment
TLDR
In this review, the role of antigen-presenting cells (APC) in MS development as well as the novel therapeutic options targeting those cells in MS are presented.
Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis
Pathogenic TH17 inflammation is sustained in the lungs by conventional dendritic cells and Toll‐like receptor 4 signaling
CD40-Mediated NF-κB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics
TLDR
It is found that memory and naive B cells from RRMS and secondary progressive MS patients exhibited a significantly elevated level of phosphorylated NF-κB (p-P65) following CD40 stimulation compared with healthy donor controls, suggesting that reducing CD40-mediated p-P 65 induction may be a general mechanism by which some current therapies modulate MS disease.
EBV Infection Empowers Human B Cells for Autoimmunity: Role of Autophagy and Relevance to Multiple Sclerosis
TLDR
EBV infection switches MOG processing in B cells from destructive to productive and facilitates cross-presentation of disease-relevant epitopes to CD8+ T cells.
Developing Connections among B Lymphocytes and Deregulated Pathways in Autoimmunity
TLDR
Following the tradition established in 2001, the conference was a forum where basic immunologists and their clinically trained colleagues met to discuss hot topics of autoimmunity research and brought considerable excitement to the conference in the refreshingly beautiful and elegant landscape of Sun Moon Lake and its indescribable charm.
The direct deleterious effect of Th17 cells in the nervous system compartment in multiple sclerosis and experimental autoimmune encephalomyelitis: one possible link between neuroinflammation and neurodegeneration
TLDR
Due to their role in preventing remyelination and direct neurotoxic effect, Th17 cells might stand for an important connection between neuroinflammation and neurodegeneration in a devastating disease like MS.
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References

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