B cells express intracellular but not surface receptors for testosterone and estradiol

  title={B cells express intracellular but not surface receptors for testosterone and estradiol},
  author={W. Peter M. Benten and Christian Stephan and Frank Wunderlich},

Estrogen augments the T cell-dependent but not the T-independent immune response

The results provide the first evidence that estrogen enhances the TD but not the TI-2 response, and show that estrogen may have a direct impact on B and T cells by inducing rapid signaling events, such as Erk and AKT phosphorylation, cell-specific Ca2+ signal, and NFκB activation.

Immunomodulation by estrogen and estren

The results show that the effects of estrogen on the immune system are mainly mediated via ERα, but signalling through ERβ is necessary for complete inhibitory effect on B lymphopoiesis.

A dynamic network of estrogen receptors in murine lymphocytes: fine‐tuning the immune response

It is shown that in lymphocytes, mERs can signalize themselves, and upon ligation, they are able to coordinate translocation of other E2Rs to the PM, implying existence of a complex, dynamic network of at least seven ER forms in murine lymphocytes: cytoplasmic and membrane‐linked forms of ERα, ERβ, or GPR30 and a mER that can receive extracellular E2 signals.

Oestrogen receptor specificity in oestradiol‐mediated effects on B lymphopoiesis and immunoglobulin production in male mice

Results clearly show that both ERα and ERβ are required for complete down‐regulation of B lymphopoiesis while only ERα is needed to up‐regulate immunoglobulin production in both bone marrow and spleen.

Localization of Estrogen Receptor in the Central Lymphoid Organs of Chickens during the Late Stage of Embryogenesis

It is indicated that estrogen affects the differentiation of thymic and bursal lymphocytes, suggesting that the underlying role for estrogen in immune function is not fully understood.

Morphological relationships and leukocyte influence on steroid production in the epigonal organ‐ovary complex of the skate, Leucoraja erinacea

In this study, the histological and vascular relationships of the EO and ovarian follicles of the little skate, Leucoraja erinacea, were assessed and provide a basis for further investigations of leukocyte secreted factors and cell contact modulation of follicular steroid production.

Influence of oestrogen receptor α and β on the immune system in aged female mice

Oestrogen has a dichotomous effect on the immune system. T and B lymphopoiesis in thymus and bone marrow is suppressed, whereas antibody production is stimulated by oestrogen. In this study the



Functional testosterone receptors in plasma membranes of T cells

The testosterone responsiveness of murine splenic T cells in vitro as well as the presence of unconventional cell surface receptors for testosterone and classical intracellular AR are demonstrated, suggesting that the classical AR present in splenicT cells are not active in the genomic pathway.

Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages.

The data provide evidence for the existence of G-protein-coupled, agonist-sequestrable receptors for testosterone in plasma membranes, which initiate a transcription-independent signaling pathway of testosterone.

Estradiol Signaling via Sequestrable Surface Receptors.

The E2-signaling initiated at the plasma membrane is mediated through neither ERα nor ERβ, but rather through a novel G protein-coupled membrane E2 -receptor as revealed by RT-PCR, flow cytometry, and confocal laser scanning microscopy.

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

  • T. PappasB. GametchuC. Watson
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1995
It is demonstrated that GH3/B6 rat pituitary tumor cells contain a membrane ER (mER), and confocal scanning laser microscopy of cells labeled live with the anti‐peptide antibody further supports a membrane localization of ER, suggesting that mER may be structurally similar to iER.

Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.

The existence of a putative membrane estrogen receptor (ER) has been supported by studies accomplished over the past 20 yr. However, the origin and functions of this receptor are not well defined. To

Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects.

The results demonstrate that 17betaE2 induces a rapid and sustained increase of intracellular calcium concentrations ([Ca2+]i), and this effect is totally dependent on the presence of extracellular calcium, because it is completely abolished in a calcium-depleted medium.

Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells.

The restriction of estrogen receptors to T cells bearing the "suppressor-cytotoxic" phenotype suggests a possible pathway for the modulation of T cell suppressive activities by estrogens.