B cells as a therapeutic target in autoimmune disease

  title={B cells as a therapeutic target in autoimmune disease},
  author={J{\"o}rg J Goronzy and Cornelia M Weyand},
  journal={Arthritis Research & Therapy},
  pages={131 - 135}
Depleting B cells with anti-CD20 monoclonal antibodies emerges as a new therapeutic strategy in autoimmune diseases. Preliminary clinical studies suggest therapeutic benefits in patients with classic autoantibody-mediated syndromes, such as autoimmune cytopenias. Treatment responses in rheumatoid arthritis have opened the discussion about whether mechanisms beyond the removal of potentially pathogenic antibodies are effective in B-cell depletion. B cells may modulate T-cell activity through… CONTINUE READING