B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice.

@article{Noorchashm1997BcellsAR,
  title={B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice.},
  author={Hooman Noorchashm and Negin Noorchashm and Jeffrey P. Kern and Susan Y. Rostami and Clyde F. Barker and Abderrahim Naji},
  journal={Diabetes},
  year={1997},
  volume={46 6},
  pages={941-6}
}
Nonobese diabetic (NOD) mice spontaneously develop an acute onset of hyperglycemia reminiscent of human type I diabetes. The disease is the end result of a mononuclear cell infiltration of pancreatic islets (insulitis), culminating in the selective destruction of islet beta-cells by autoreactive T-cells. NOD mice also exhibit defects in B-cell tolerance as manifested by the presence of autoantibodies against islet cell autoantigens. Based on the potential ability of B-cells to act as antigen… CONTINUE READING