B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection.

@article{Lund2006BCA,
  title={B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection.},
  author={Frances E. Lund and Melissa L. Hollifield and Kevin M Schuer and J. Louise Lines and Troy D. Randall and Beth A. Garvy},
  journal={Journal of immunology},
  year={2006},
  volume={176 10},
  pages={6147-54}
}
B cell-deficient mice are susceptible to infection by Pneumocystis carinii f. sp. muris (PC). To determine whether this susceptibility is due to a requirement for B cells to prime T cells, we compared CD4 T cell responses to PC in bone marrow chimeric mice that express MHC class II (MHCII) on all APCs (wild-type (WT) chimeras) and in bone marrow chimeric mice that express MHCII on all APCs except B cells (MHCII(-/-) chimeras). Although PC was rapidly cleared by WT chimeric mice, PC levels… CONTINUE READING