B-cells and their targeting in rheumatoid arthritis--current concepts and future perspectives.

Abstract

Rheumatoid arthritis (RA) is a chronic, autoimmune disease that affects primarily the joints and without proper treatment results in their progressive destruction. In addition to T-cells, B-cells play a central role in the pathogenesis of this disease. The synovial tissue is an active site of B-cell accumulation, plasma cell differentiation and in situ… (More)
DOI: 10.1016/j.autrev.2011.06.010

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