B cells and tertiary lymphoid structures promote immunotherapy response

@article{Helmink2020BCA,
  title={B cells and tertiary lymphoid structures promote immunotherapy response},
  author={B. Helmink and S. Reddy and Jianjun Gao and S. Zhang and R. Basar and Rohit Thakur and Keren Yizhak and M. Sade-Feldman and J. Blando and Guangchun Han and V. Gopalakrishnan and Y. Xi and H. Zhao and R. Amaria and H. Tawbi and Alexandria P. Cogdill and Wenbin Liu and V. LeBleu and Fernanda G Kugeratski and S. Patel and M. Davies and P. Hwu and Jeffrey E. Lee and J. Gershenwald and A. Lucci and R. Arora and S. Woodman and E. Keung and P. Gaudreau and A. Reuben and C. Spencer and E. Burton and L. Haydu and A. Lazar and Roberta Zapassodi and C. Hudgens and D. Ledesma and S. Ong and Michael D. Bailey and S. Warren and D. Rao and O. Krijgsman and E. A. Rozeman and D. Peeper and C. Blank and T. Schumacher and L. Butterfield and M. Zelazowska and K. McBride and R. Kalluri and J. Allison and F. Petitprez and W. Fridman and C. Saut{\`e}s-Fridman and N. Hacohen and K. Rezvani and P. Sharma and M. Tetzlaff and L. Wang and J. Wargo},
  journal={Nature},
  year={2020},
  volume={577},
  pages={549-555}
}
Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers 1 – 10 and strategies to augment clinical response have largely focused on the T cell compartment. However, other immune subsets may also contribute to anti-tumour immunity 11 – 15 , although these have been less well-studied in ICB treatment 16 . A previously conducted neoadjuvant ICB trial in patients with melanoma showed via targeted expression profiling 17 that B cell… Expand
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