B cells and antibodies in CNS demyelinating disease

@article{Cross2001BCA,
  title={B cells and antibodies in CNS demyelinating disease},
  author={Anne H. Cross and John L. Trotter and J Lyons},
  journal={Journal of Neuroimmunology},
  year={2001},
  volume={112},
  pages={1-14}
}
There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps… CONTINUE READING

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