B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.

@article{Saini2015BCV,
  title={B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.},
  author={Jasmine Saini and Uri Hershberg},
  journal={Molecular immunology},
  year={2015},
  volume={65 1},
  pages={157-67}
}
The exceptional ability of B cells to diversify through somatic mutation and improve affinity of the repertoire toward the antigens is the cornerstone of adaptive immunity. Somatic mutation is not evenly distributed and exhibits certain micro-sequence specificities. We show here that the combination of somatic mutation targeting and the codon usage in human B cell receptor (BCR) Variable (V) genes create expected patterns of mutation and post mutation changes that are focused on their… CONTINUE READING
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