B-cell therapies for rheumatoid arthritis.

  title={B-cell therapies for rheumatoid arthritis.},
  author={Jose U. Scher},
  journal={Bulletin of the NYU hospital for joint diseases},
  volume={70 3},
  • Jose U. Scher
  • Published 2012 in Bulletin of the NYU hospital for joint diseases
B cells were originally considered key mediators in the pathogenesis of rheumatoid arthritis (RA). The presence of these cells in many RA synovial tissues and the discovery of rheumatoid factor had put B cells originally at the center of disease pathogenesis. That enthusiasm vanished shortly thereafter only to resurface in the last 15 years with the appearance of highly specific anti-cyclic citullinated protein antibodies. Rituximab, an anti-CD20 antibody that depletes mature B cells, was… CONTINUE READING
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