B-cell-targeted therapies in systemic lupus erythematosus

  title={B-cell-targeted therapies in systemic lupus erythematosus},
  author={Vera Sau-Fong Chan and Helen Hoi-Lun Tsang and Rachel Chun-Yee Tam and Liwei Lu and Chak-sing Lau},
  journal={Cellular and Molecular Immunology},
Autoreactive B cells are one of the key immune cells that have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). In addition to the production of harmful auto-antibodies (auto-Abs), B cells prime autoreactive T cells as antigen-presenting cells and secrete a wide range of pro-inflammatory cytokines that have both autocrine and paracrine effects. Agents that modulate B cells may therefore be of potential therapeutic value. Current strategies include targeting B-cell… CONTINUE READING
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