B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide.

@article{Snapper1987BCS,
  title={B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide.},
  author={Clifford M Snapper and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  journal={Journal of immunology},
  year={1987},
  volume={139 1},
  pages={10-7}
}
B cell stimulatory factor-1 (BSF-1)/interleukin 4 markedly enhances IgG1 and IgE secretion by B cells stimulated with bacterial lipopolysaccharide (LPS). We show that preincubation of resting B cells with BSF-1 alone prepares them to secrete IgG1, but not IgE, on subsequent stimulation with LPS. The ability of BSF-1 preincubation to increase overall viable cell yield on the subsequent addition of LPS only partially accounts for this enhancement. The degree of enhancement is dependent on the… CONTINUE READING

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