B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element

@article{Werner2004BcellspecificTE,
  title={B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element},
  author={Michel Werner and Janine Kraunus and Christopher C. Baum and Thomas Brocker},
  journal={Gene Therapy},
  year={2004},
  volume={11},
  pages={992-1000}
}
Retroviral gene transfer resulting in transgene expression selectively restricted to specific cell lineages would be desirable for many gene therapeutic applications. Such transcriptional targeting of retroviruses can be accomplished by employing eukaryotic control elements in self-inactivating (SIN) retroviral vectors, but use of these vectors is complicated by an accompanying reduction in viral titers. To overcome this restriction and address the influence of the post-transcriptional… CONTINUE READING
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