B cell-specific activation of the Epstein-Barr virus-encoded C promoter compared with the wide-range activation of the W promoter.

@article{ContrerasBrodin1996BCA,
  title={B cell-specific activation of the Epstein-Barr virus-encoded C promoter compared with the wide-range activation of the W promoter.},
  author={B A Contreras-Brodin and Ann Karlsson and Tina Nilsson and L. Rymo and George Klein},
  journal={The Journal of general virology},
  year={1996},
  volume={77 ( Pt 6)},
  pages={1159-62}
}
We have studied the activity of reporter plasmids, carrying the Epstein-Barr virus (EBV) nuclear antigen (EBNA) promoters Wp and Cp, in a group of somatic cell hybrids obtained by fusing EBV-positive lymphoblastoid cell lines or group II/III Burkitt's lymphoma cell lines with non-B cell lines. In B/non-B cell hybrids of this type, B cell markers are extinguished as a rule, in parallel with the inactivation of Cp or Wp and down-regulation of EBNA-2-6 expression. A Wp-carrying reporter construct… CONTINUE READING