B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.

Abstract

Many prion diseases are peripherally acquired (e.g., orally or via lesions to skin or mucous membranes). After peripheral exposure, prions replicate first upon follicular dendritic cells (FDC) in the draining lymphoid tissue before infecting the brain. However, after replication upon FDC within the draining lymphoid tissue, prions are subsequently… (More)
DOI: 10.4049/jimmunol.1200349

Topics

Cite this paper

@article{Mok2012BCS, title={B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.}, author={Simon Mok and Richard L Proia and Volker Brinkmann and Neil A Mabbott}, journal={Journal of immunology}, year={2012}, volume={188 10}, pages={5032-40} }