B-cell selection and the development of autoantibodies

  title={B-cell selection and the development of autoantibodies},
  author={Natalia V. Giltiay and Craig P. Chappell and Edward A. Clark},
  booktitle={Arthritis research & therapy},
The clearest evidence that B cells play an important role in human autoimmunity is that immunotherapies that deplete B cells are very effective treatments for many autoimmune diseases. All people, healthy or ill, have autoreactive B cells, but not at the same frequency. A number of genes influence the level of these autoreactive B cells and whether they are eliminated or not during development at a central checkpoint in the bone marrow (BM) or at a later checkpoint in peripheral lymphoid… CONTINUE READING
Highly Cited
This paper has 41 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 21 extracted citations

Protein Reviews

Advances in Experimental Medicine and Biology • 2017


Publications referenced by this paper.
Showing 1-10 of 116 references

Germinal centers.

Annual review of immunology • 2012