B-cell selection and the development of autoantibodies

@inproceedings{Giltiay2012BcellSA,
  title={B-cell selection and the development of autoantibodies},
  author={Natalia V. Giltiay and Craig P. Chappell and Edward A. Clark},
  booktitle={Arthritis research & therapy},
  year={2012}
}
The clearest evidence that B cells play an important role in human autoimmunity is that immunotherapies that deplete B cells are very effective treatments for many autoimmune diseases. All people, healthy or ill, have autoreactive B cells, but not at the same frequency. A number of genes influence the level of these autoreactive B cells and whether they are eliminated or not during development at a central checkpoint in the bone marrow (BM) or at a later checkpoint in peripheral lymphoid… CONTINUE READING
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