B cell responses to a peptide epitope. X. Epitope selection in a primary response is thermodynamically regulated.

@article{Nakra2000BCR,
  title={B cell responses to a peptide epitope. X. Epitope selection in a primary response is thermodynamically regulated.},
  author={Pooja Nakra and Venkatasamy Manivel and Ram A Vishwakarma and Kanury V S Rao},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={5615-25}
}
We examine the etiological basis of hierarchical immunodominance of B cell epitopes on a multideterminant Ag. A model T-dependent immunogen, containing a single immunodominant B cell epitope, was used. The primary IgM response to this peptide included Abs directed against diverse determinants presented by the peptide. Interestingly, affinity of individual monomeric IgM Abs segregated around epitope recognized and was independent of their clonal origins. Furthermore, affinity of Abs directed… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…