B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides.

@article{Schwamb2012BcellRT,
  title={B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides.},
  author={Janine Schwamb and Valeska Feldhaus and Michael Baumann and Michaela Patz and Susanne Brodesser and Reinhild Brinker and Julia Claasen and Christian Pallasch and Michael J Hallek and C M Wendtner and Lukas P. Frenzel},
  journal={Blood},
  year={2012},
  volume={120 19},
  pages={3978-85}
}
Survival of chronic lymphocytic leukemia (CLL) cells is triggered by several stimuli, such as the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4). We identified that these stimuli regulate apoptosis resistance by modulating sphingolipid metabolism. Applying liquid chromatography electrospray ionization tandem mass spectrometry, we revealed a significant decrease of proapoptotic ceramide in BCR/IL-4/CD40L-stimulated primary CLL cells compared with untreated controls… CONTINUE READING
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