B cell receptor signalling in chronic lymphocytic leukaemia cells is regulated by overexpressed active protein kinase CβII

Abstract

Signals through the B-cell antigen receptor (BCR) are important for the survival of chronic lymphocytic leukaemia (CLL) cells. Therefore, factors that influence these signals have important pathophysiological roles in this disease. One key mediator of BCR signalling is protein kinase C β (PKCβ), which regulates activation of I-κB kinases and deactivation of… (More)

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