B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.

Abstract

We have developed a microarray to study the expression of L-chain V genes (V(L) genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V(L) gene accounts for over 10% of all gene V(L) expression, consistent with positive selection acting on L-chains. While a few V(L) genes were highly expressed in all… (More)
DOI: 10.1016/j.molimm.2012.03.028

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