B cell receptor editing in tolerance and autoimmunity.

  title={B cell receptor editing in tolerance and autoimmunity.},
  author={Hilla Azulay-Debby and Doron Melamed},
  journal={Frontiers in bioscience : a journal and virtual library},
The random assembly of immunoglobulin (Ig) genes often creates a B cell receptor that is self-reactive, and such cells are subjected to negative selection. A primary mechanism to extinguish this self-reactivity is receptor editing, which allows continued recombination of Ig genes and replacement of the self-reactive receptor with a new innocuous receptor. Recent data now suggest that receptor editing may also promote autoimmunity in an autoimmune context. This mechanism has also been implicated… CONTINUE READING
Highly Cited
This paper has 56 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 24 extracted citations

56 Citations

Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 150 references