B cell receptor editing in tolerance and autoimmunity.

@article{AzulayDebby2007BCR,
  title={B cell receptor editing in tolerance and autoimmunity.},
  author={Hilla Azulay-Debby and Doron Melamed},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          2136-47
        }
}
The random assembly of immunoglobulin (Ig) genes often creates a B cell receptor that is self-reactive, and such cells are subjected to negative selection. A primary mechanism to extinguish this self-reactivity is receptor editing, which allows continued recombination of Ig genes and replacement of the self-reactive receptor with a new innocuous receptor. Recent data now suggest that receptor editing may also promote autoimmunity in an autoimmune context. This mechanism has also been implicated… CONTINUE READING
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