B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.

@article{Kempkes1995BcellPA,
  title={B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.},
  author={Bettina Kempkes and Dimitry Spitkovsky and Pidder Jansen-Duerr and J. Ellwart and Elisabeth Kremmer and H J Delecluse and C Rottenberger and Georg W. Bornkamm and Wolfgang Hammerschmidt},
  journal={The EMBO journal},
  year={1995},
  volume={14 1},
  pages={88-96}
}
Infection of primary B-lymphocytes by Epstein-Barr virus (EBV) leads to growth transformation of these B-cells in vitro. EBV nuclear antigen 2 (EBNA2), one of the first genes expressed after EBV infection of B-cells, is a transcriptional activator of viral and cellular genes and is essential for the transforming potential of the virus. We generated conditional EBV mutants by expressing EBNA2 as chimeric fusion protein with the hormone binding domain of the estrogen receptor on the genetic… CONTINUE READING
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