B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.

@article{Nacionales2009BCP,
  title={B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.},
  author={Dina C. Nacionales and Jason Scott Weinstein and Xiao-Jie Yan and Emilia Albesiano and Pui Y Lee and Kindra M Kelly-Scumpia and Robert B. Lyons and Masao Satoh and Nicholas Chiorazzi and Westley Hubbard Reeves},
  journal={Journal of immunology},
  year={2009},
  volume={182 7},
  pages={
          4226-36
        }
}
Intraperitoneal exposure of nonautoimmune mice to 2,6,10,14-tetramethylpentadecane (TMPD) causes lupus and the formation of ectopic lymphoid tissue. Although associated with humoral autoimmunity, it is not known whether Ab responses develop within ectopic lymphoid tissue or if B cells only secondarily migrate there. We show that ectopic lymphoid tissue induced by TMPD not only resembles secondary lymphoid tissue morphologically, but it also displays characteristics of germinal center reactions… CONTINUE READING
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