B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.

@article{Pelanda2002BCP,
  title={B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.},
  author={Roberta Pelanda and Uschi Braun and Elias Hobeika and Michel C. Nussenzweig and Michael Reth},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={865-72}
}
Ig-alpha and Ig-beta mediate surface expression and signaling of diverse B cell receptor complexes on precursor, immature, and mature B cells. Their expression begins before that of the Ig chains in early progenitor B cells. In this study, we describe the generation of Ig-alpha-deficient mice and their comparative analysis to mice deficient for Ig-beta, the membrane-IgM, and recombination-activating gene 2 to determine the requirement of Ig-alpha and Ig-beta in survival and differentiation of… CONTINUE READING

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