B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases.

@article{Palanivel1996BcellOA,
  title={B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases.},
  author={Vidhya Palanivel and Claude F. Posey and A M Horauf and W Solbach and Willy F. Piessens and Donald A. Harn},
  journal={Experimental parasitology},
  year={1996},
  volume={84 2},
  pages={168-77}
}
In many parasitic infections, dominant T helper cell (Th) type-2 CD4+ T cell responses exacerbate the disease. We have previously demonstrated that lacto-N-fucopentaose-III (LNFPIII), a sugar found on soluble egg antigens (SEA) of Schistosoma mansoni, stimulates splenic B cells from parasite-infected mice to proliferate and produce IL-10, a cytokine that promotes the generation of Th2 immune responses. In the present study, we extend our observations on ligand-specific activation of IL-10… CONTINUE READING

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