B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activating factor are candidate mediators of spinal cord injury-induced autoimmunity.

@article{Saltzman2013BcellMA,
  title={B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activating factor are candidate mediators of spinal cord injury-induced autoimmunity.},
  author={Jonah W Saltzman and Ricardo A. Battaglino and Loise Pedrosa Salles and Prateek K Jha and Supreetha Sudhakar and Eric Garshick and Helen L Stott and Ross Zafonte and Leslie R. Morse},
  journal={Journal of neurotrauma},
  year={2013},
  volume={30 6},
  pages={434-40}
}
Autoimmunity is thought to contribute to poor neurological outcomes after spinal cord injury (SCI). There are few mechanism-based therapies, however, designed to reduce tissue damage and neurotoxicity after SCI because the molecular and cellular bases for SCI-induced autoimmunity are not completely understood. Recent groundbreaking studies in rodents indicate that B cells are responsible for SCI-induced autoimmunity. This novel paradigm, if confirmed in humans, could aid in the design of… CONTINUE READING
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