B-cell lymphoproliferative disorders in solid-organ transplant patients: detection of Epstein-Barr virus by in situ hybridization.

@article{Berg1992BcellLD,
  title={B-cell lymphoproliferative disorders in solid-organ transplant patients: detection of Epstein-Barr virus by in situ hybridization.},
  author={Lothar Berg and Christine Copenhaver and Virginia Morrison and Scott Gruber and David L. Dunn and Kazimiera J. Gajl-Peczalska and John G. Strickler},
  journal={Human pathology},
  year={1992},
  volume={23 2},
  pages={159-63}
}
B-cell lymphoproliferative disorders (BLPDs) occur in approximately 2% of transplant recipients and are frequently fatal. Indirect serologic evidence has implicated Epstein-Barr virus (EBV) as an etiologic factor in these lesions. Direct evidence of the presence of EBV in these lesions has been obtained in relatively few cases. We used in situ hybridization (ISH) with a probe for the BamHI-W region of the EBV genome to study 52 tissue specimens from 28 solid-organ transplant patients who had… CONTINUE READING
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