B cell lineages: documented at last!

  title={B cell lineages: documented at last!},
  author={Leonore Herzenberg and James W. Tung},
  journal={Nature Immunology},
In this issue of Nature Immunology, MontecinoRodriguez, Leathers and Dorshkind put an end to a controversy that has simmered and bubbled for nearly 15 years. In what should become a landmark paper, these authors report the isolation of phenotypically distinct progenitors for mouse B-1a, B-1b and B-2 cells at an early developmental stage, well before rearrangement of the gene encoding the immunoglobulin heavy-chain complex (Igh) is complete1. Thus, despite heated arguments to the contrary, these… CONTINUE READING


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