B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.

  title={B cell homeostasis and plasma cell homing controlled by Kr{\"u}ppel-like factor 2.},
  author={Rebecca Winkelmann and Lena Sandrock and Martina Porstner and Edith A. Roth and Martina Mathews and Elias Hobeika and Michael Reth and Mark L. Kahn and Wolfgang Schuh and Hans-Martin J{\"a}ck},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 2},
Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells. Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β(7)-integrin. In mice with a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all… CONTINUE READING


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