B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10.

Abstract

In these studies we show that although purified B cells of patients with common variable immunodeficiency (CVI) have a normal capacity to proliferate, they manifest differentiation defects at multiple levels. Compared with controls, circulating CVI B cell populations contain reduced numbers of sIgG+ and sIgA+ cells with a commensurate increase in sIgM+ B… (More)

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Cite this paper

@article{Eisenstein1994BCD, title={B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10.}, author={Eric M. Eisenstein and Kevin S. Chua and Warren Strober}, journal={Journal of immunology}, year={1994}, volume={152 12}, pages={5957-68} }