B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes.

@article{Tosato1980BCD,
  title={B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes.},
  author={Giovanna Tosato and Ian T. Magrath and Irma R. Koski and N J Dooley and R. Michael Blaese},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={66 2},
  pages={
          383-8
        }
}
The functional maturity of T and B lymphocyte populations from human newborns was evaluated using a reverse hemolytic plaque assay to detect immunoglobulin-secreting cells generated in in vitro cultures stimulated with pokeweed mitogen (PWM), a T cell-dependent polyclonal activator, and the Epstein-Barr virus (EBV), a T cell-independent B cell activator. Cord blood lymphocytes failed to produce immunoglobulin in response to PWM, but did respond with immunoglobulin synthesis to stimulation with… CONTINUE READING

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Immunology of the Neonate

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